BioPharmaSpec provides a complete solution for Filgrastim and pegylated Filgrastim comparability, biosimilarity and characterization studies.
Filgrastim (trade name Neupogen) is a G-CSF analog used to stimulate the bone marrow to produce granulocytes and stem cells. Pegfilgrastim is a PEGylated form of G-CSF often used to fight infection in patients undergoing chemotherapy. PEGylation of recombinant biopharmaceutical products is performed to increase the half-life of the product. For example, Pegfilgrastim has a human half-life of 15-80 hours, compared to Filgrastim’s half-life of 3–4 hours.