De-novo sequencing
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Definition
De-novo sequencing refers to sequencing the amino-acid chain of a protein where there is no reference/ target sequence available. In protein chemistry there are two methods used to achieve the sequence of a novel protein- 1. Gas Phase (Edman) sequencing and 2. mass spectrometry using MS/MS methods. BPS provide both of these methods together with expert interpretation of data.
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Case Study
European Biosimilar Company – Structural And Physicochemical Characterization And Comparability
Our client is developing a biosimilar to Simponi and required studies including determination of the primary sequence of an EU RMP Golimumab sample and a structural and physicochemical comparability assessment of three EU RMP Golimumab samples.
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