Disulfide bridges definition

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Definition

Disulfide bridges, or disulfide bonds or S-S bonds, are covalent links between the Sulphur atoms of two cysteine amino acids. The disulfide bridging pattern of a biopharmaceutical stabilizes its tertiary and higher order structure.

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Knowledge Center

Dealing with the Challenges of Disulfide Bridge Analysis in Biopharmaceuticals Read More

Case Study

ScinoPharm Taiwan Ltd. – Disulfide Bridge Analysis of Linaclotide

ScinoPharm Taiwan Ltd. required a structural assessment of the disulfide bridges in various Linaclotide samples, a challenging project which starts with fragmenting a tightly bound structure.