Glucocerebrosidase

Categories: Glossary: Glycosylation , mass spectrometry

Definition

Glucocerebrosidase is an enzyme which breaks down the glycolipid glucocerebroside into glucose and ceramide inside lysosomes. An inherited disorder, Gaucher disease, is caused when this does not function correctly.

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Case Study

Iksuda Therapeutics – Oligosaccharide Profiling of an ADC

Iksuda required glycosylation analysis for their Antibody Drug Conjugate product to provide functionally important post-translational modification information and to ensure that the chemistry used to attach the drug did not impact glycosylation.