Methylation
Categories:
Glossary: Peptide Mapping
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impurities
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mass spectrometry
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post translational modification
Definition
A post-translational modification involving the addition of a methyl group at various residues (commonly lysine or arginine). The reverse reaction is called demethylation.
BioPharmaSpec assesses for methylation using a combination of intact molecular weight analysis (to show a mass difference from the expected) and peptide mapping (to confirm the PTM and assess for the site of the modification).