Orthogonality

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Definition

Orthogonal methods use different techniques or underlying principles to measure the same parameter. Orthogonality reduces bias and selectivity in individual methods so that more reliable conclusions can be drawn.

Related Content & Resources

Knowledge Center

Building Orthogonality into Your Analytical and Characterization Plans – Part 1 Read More
Building Orthogonality into Your Analytical and Characterization Plans – Part 2 Read More

Case Study

European Biosimilar Company – Structural And Physicochemical Characterization And Comparability

Our client is developing a biosimilar to Simponi and required studies including determination of the primary sequence of an EU RMP Golimumab sample and a structural and physicochemical comparability assessment of three EU RMP Golimumab samples.