Publications

Publication: Understanding Biosimilars (Primary amino acid sequencing)

The primary amino acid sequence of a biosimilar must be identical to that of its associated innovator. This article describes these regulations and the sequencing techniques that can be used to meet the guidelines.

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Publication: Dissecting Structures (Higher Order Structure Determination)

This publication discusses the analytics that should be performed within a biophysical characterization, comparability or biosimilarity study in order to define higher order protein structure.

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Publication: Physicochemical Characterization of Insulin

Four well-established techniques: dynamic light scattering (DLS), circular dichroism (CD), nuclear magnetic resonance spectroscopy (NMR), and molecular modelling are combined to provide structural information about insulin.

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Publication: O-linked Carbohydrate Characterization

The characterization of O-linked glycosylation requires specific technical expertise and experience. In this paper, our scientists document glycosylation of the C-terminal threonine of the surface glycoprotein of 5 of 5 strains of HIV-1.

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Publication: Sialic Acid Characterization

Pang, P.C. et al: Human Sperm Binding is Mediated by Sialyl-Lewis(X) Oligosaccharide on Zona Pellucida. Science 333, 1761-1764 (2011)

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Publication: Glycoproteomics: Past, Present and Future

Morris, H.R. et al: Glycoproteomics: Past, Present and Future. Int. J. Mass Spectrom. 259, 16-31 (2007)

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Publication: N-linked Glycosylation

Wacker, M. et al: N-Linked Protein Glycosylation in Campylobacter jejuni and its Functional Transfer into Escherichia coli. Science 298, 1790-1793 (2002)

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Publication: Presentation of QTOF-MS

Morris,H.R et al: High sensitivity collisionally-activated decomposition tandem mass spectrometry on a novel quadrupole/orthogonal-acceleration time-of-flight mass spectrometer. Rapid Communications in Mass Spectrometry 10, 889-896 (1996)

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Publication: Disulfide Bridge Scrambling (Insulin)

Morris, H.R. et al: Protein Folding/Refolding Analysis by Mass Spectrometry: Scrambling of Disulphide Bridges in Insulin. Biochem. J. 268, 803-806 (1990)

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Publication: Assignment of Disulfide Bridge Positions

Morris, H.R. & Pucci, P.: A New Method for Rapid Assignment of S-S Bridges in Proteins. Biochem. Biophys. Res. Commun. 126, 1122-1128 (1985)

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